Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis

نویسندگان

  • Yoshifumi Murata
  • Kyoko Kofuji
  • Norihisa Nishida
  • Ryosei Kamaguchi
چکیده

Film dosage forms (FDs) containing allopurinol (AP) were prepared using a casting method with water-soluble polysaccharides, such as sodium alginate (ALG), and the release profile of AP from FDs was investigated in limited dissolution medium. Some ALGs were able to form FDs incorporating AP, and the thickness was about 50 μm. All FDs were easy to handle, though the rheological properties varied with ALG species. AP was homogenously present throughout the FDs and was released with disintegration in 10 mL of physiological saline. These results confirmed that FDs are useful for preventing or treating localized problems in the oral cavity, such as mucositis. FDs are also useful for administering drugs to cancer patients receiving chemotherapy and/or radiotherapy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mouth-rinses for the prevention of chemotherapy induced oral mucositis in children: a systematic review

Abstract Background The purpose of this review was to evaluate studies in basic oral care interventions to update evidence based practice guidelines for preventing oral mucositis (OM) in cancer patients undergoing chemotherapy. Material & Methods Pub Med database and Google Scholar were searched for all papers published between 2000 and December 2014 in English that were conducted using t...

متن کامل

Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial

Background: This research was conducted to evaluate the potential benefits of zinc sulphate in the prevention of radiation induced mucositis in patients who are being treated for head and neck cancers. Materials and Methods: Forty patients with proven cancers of head and neck were randomly divided into 2 equal groups that either received zinc sulphate or placebo (control group). Patients who re...

متن کامل

Comparison of Radiation-Induced Mucositis With Multiple Oral Ulcers Based on Iranian Traditional Medicine: A Review Study

Objective Radiation-Induced Mucositis (RIM) is more common in patients with head and neck cancers. Common medications have not been fully successful in preventing and treating RIM. We can use the potential of Iranian medicine for prevention and oral/topical treatment of these lesions.  Methods In this review study, the keywords of “Mucositis”, “Head and Neck Radiotherapy”, “Aphthous”, and “Mou...

متن کامل

The Effect of Oral Selenium on Radiotherapy Induced Mucositis in Patients with Head and Neck Cancer:a Pilot double-blind study

Background & Aims: The purpose of this study was to evaluate the efficacy of oral selenium in alleviation of oral mucositis induced by radiotherapy in head and neck cancer patients. Methods: In a randomized double blind pilot study, 35 patients under radiotherapy, due to primary tumors localized in the head or neck, who had at least two oral sites were studied. They were randomly divided into t...

متن کامل

The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer

Background: To investigate the effect of zinc sulphate for prophylaxis of radiation-induced oral mucositis in patients with head and neck cancer. Materials And Methods: In the department of Radiation Oncology, Ankara Numune Education and Research Hospital, 40 patients with head and neck cancer were selected randomly to receive either Zinco-C 25 mg, four tablets daily or control group who did no...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2012  شماره 

صفحات  -

تاریخ انتشار 2012